The South African Medical Research Council Malaria Research Group (MRG) seeks to improve the health and quality of life of people living in malaria endemic areas by facilitating high quality scientific research that informs the development of policy, health services, health promotion and capacity development. In consultation with the SA National Department of Health the MRG developed a prioritised research agenda to foster networking and collaboration among different role players to synergise efforts on malaria research towards a common goal. In light of this it was decided to host the first malaria research conference in 2015 which has now become an annual event.